The lack of hhv8 in pseudokaposis acroangiodermatitis, as was the case in our patient, demonstrates that the determination of hhv8 by pcr is the most important. The clinicopathologic distinctions between kaposis sarcoma and pseudokaposis lesions are discussed. Validation of solar thermal pcr for the diagnosis of kaposis sarcoma using pseudobiopsy samples ryan snodgrass 0 1 andrea gardner 0 1 li jiang 0. Hi, your search found this article for you on trip. May i add to the references already mentioned the report of a case that i published. Kaposi sarcoma ks is an angioproliferative disorder that requires infection with human herpes virus 8 hhv8, also known as kaposi sarcomaassociated herpes virus kshv, for its development. Kaposis sarcoma is a vascular neoplasm mainly affecting the skin of the lower extremities. Acroangiodermatitis of mali, which is also referred to as simply acroangiodermatitis or pseudokaposi sarcoma, is a rare vascular phenomenon with skin manifestations characterized by violaceous nodules or plaques arising from hyperplasia of preexisting vasculature due to severe chronic venous insufficiency cvi and associated venous hypertension. Histological findings on a biopsy corroborated the diagnosis of pseudo. Acroangiodermatitis mali resulting from arteriovenous malformation. Ultrastructural study of pseudokaposis sarcoma bluefarb. If you do not see its contents the file may be temporarily unavailable at the journal website or you do not have a pdf plugin installed and enabled in your browser.
Lesions may also develop in the digestive tract, liver, or lungs. This disease must be distinguished from kaposi sarcoma because of their clinical resemblance. Prevalence of kaposis sarcomaassociated herpesvirus and transfusiontransmissible infections in tanzanian blood donors. Appointment reminders to increase uptake of hiv retesting by atrisk individuals. Although it is the most common neoplasm affecting patients with aids, sporadic cases in hivnegative people have been reported. The neoplasm consisted of a proliferation of vascular structures mostly consisting of a solid bud of endothelial cells surrounded by a thinned and polystratified basement membrane and several pericytes. It is a lesion mainly affecting men and its clinical presentation presents a challenge, as it can resemble other benign or malignant skin lesions. Ks generally occurs in people with weakened immune systems. This was once considered an uncommon cancer and then it started to affect people with hiv because of their weaken immune system. Acroangiodermatitis, also known as pseudokaposi sarcoma is a reactive angiodysplasia of cutaneous blood vessels often seen in association with venous insufficiency or with certain vascular anomalies. Pathology of acroangiodermatitis pseudokaposis sarcoma. Hhv8 in skin lesions of patients with kaposi sarcoma provides the most definitive confirmation of the diagnosis 1. A case on the plantar aspect of the foot associated with chronic venous insufficiency. Etiology and pathogenesis, inducing factors, causal associations, and treatments.
Kaposi sarcoma protocol pretreatment documentation date of hiv diagnosis. I have just read a paper by earhart et al on pseudokaposi sarcoma in the archives 110. Pseudokaposi sarcoma acroangiodermatitis treatment, 2014. The mali type is seen in chronic venous insufficiency and in those patients with arteriovenous shunts. Physical examination showed chronic venous insufficiency of both lower extremities. Such cases of av malformations with skin changes resembling kaposis sarcoma have been called pseudokaposis sarcoma. In people with hiv, ks is an aidsdefining condition. Kaposis sarcoma of the hand mimicking squamous cell. Echocardiogram, pulmonary function tests front back. Acroangiodermatitis pseudokaposi sarcoma as part of. Pseudokaposi sarcoma jama dermatology jama network.
Expression of the cd34 antigen distinguishes kaposis sarcoma from pseudokaposis sarcoma. Acroangiodermatitis synonym, pseudokaposi sarcoma is a benign, uncommon, acquired disease of blood vessels that commonly affects elderly male patients, and. Acroangiodermatitis of mali stewartbluefarb syndrome acroangiodermatitis is a benign vascular process which histologically closely resembles kaposis sarcoma and had thus been named pseudokaposis sarcoma acroangiodermatitis is often associated with different disorders like. It is a benign condition which clinically presents as violaceous macules, indurated plaques or nodules usually bilaterally on the extensor surfaces of lower extremities. Mesenchymomas, which are sarcomas made up of embryonic connective tissue mesenchyma, are distinguished from sarcomas made up of mature tissues of mesenchymal origin, for example, bone sarcomas osteosarcomas, cartilaginous sarcomas chondrosarcomas, vascular sarcomas angiosarcomas, hematopoietic sarcomas. Subsequent examination yielded a correct diagnosis of arteriovenous av malformation. Arteriovenous malformation simulating kaposis sarcoma. Factor viii associated antigen is seen in pseudokaposi lesions, however they are absent in kaposi sarcoma. Grupper c, elalouf c, girard j, vergoz l 1969 kaposi or pseudokaposi malis acroangiodermatitis. Moritz kaposi, a hungarian physician and dermatologist. Kaposis sarcoma ks kaposis sarcoma ks is a tumor caused by human herpesvirus 8 hhv8, also known as kaposis sarcomaassociated herpesvirus kshv. It can appear in various vascular conditions such as stewartbluefarb syndrome and chronic venous insufficiency of the lower extremities called acroangiodermatitis of mali, and limb anomalies.
It was originally described by moritz kaposi ka po she, a hungarian. Herein, we present a patient with pseudokaposi sarcoma, which developed after bullous erysipelas. If an internal link led you here, you may wish to change the link to point directly to the. This disambiguation page lists articles associated with the title kaposi. There are reported cases of pseudokaposis sarcoma of the. Kaposis sarcoma ks is a vascular tumor that was brought to the attention of the medical community over a century ago in a fascinating case series in which purplecoloured nodular skin lesions were observed on. Pdf acroangiodermatitis pseudokaposis sarcoma in an. Acroangiodermatitis pseudokaposis sarcoma associated with klippeltrenaunay syndrome. An ultrastructural study of the skin lesion of a young patient affected by pseudokaposis sarcoma of the bluefarbstewart type bss is reported. Tcell primary effusion lymphoma with pseudomonoclonal. Download fulltext pdf download fulltext pdf download fulltext pdf acroangiodermatitis pseudokaposis sarcoma in an hiv seropositive patient with syphilis and hepatitis c virus coinfection. Acroangiodermatitis or pseudokaposi sarcoma is a rare angioproliferative entity, related to chronic venous insufficiency or certain other vascular anomalies. Kaposi sarcoma ks causes red or purple patches of tissue lesions to grow under the skin and in the lining of the mouth, nose, and throat. Pretreatment evaluations fbc, chemistries, buncr, cxr, abdominal ultrasound where available.
Kaposis sarcoma kaposis sarcoma is a skin cancer that affects many parts of the body but mainly the skin, mouth and lymph nodes. Hhv8 has been found in all the forms of kaposis sarcoma. Thus, they proposed the designation of pseudokaposis sarcoma. A search for hhv8 in the lesional skin which is a characteristic feature in kaposi sarcoma can also be helpful in differential diagnosis 11.
Acroangiodermatitis of mali is a rare cutaneous condition often characterized by purplishblue to brown papules and plaques on the medial and lateral malleolus of both legs 1604 acroangiodermatitis is a rare skin condition characterised by hyperplasia of preexisting vasculature due to venous hypertension from severe chronic venous stasis. Media in category histopathology of kaposis sarcoma the following 14 files are in this category, out of 14 total. Ks is classified into four types based on the clinical circumstances in which it develops. Download acrobat pdf file 1mb recommended articles citing articles 0 references. Immunohistochemistry using the cell block showed the atypical cells were positive for cd4 panel d, kaposi sarcoma herpesvirus kshv panel e, and epsteinbarr virus in situ hybridization but negative for the rest of the tcell antigens and all bcell antigens including octamer binding protein 2 panel f and data not shown.
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